Mouse Clinical Institute-PHENOMIN National Infrastructure

Strasbourg, France

Dott. Yann Herault

He is the director of ICS and Deputy Director of IGBMC (M) and is a Research Director (DR) at the CNRS, the French National Center for Scientific Research. As a biologist and a mouse geneticist by training, he leads the Institut Clinique de la Souris (" Mouse Clinical Institute" MCI/ICS), and is a research group leader at the IGBMC (Institut de Génétique et Biologie Moléculaire et Cellulaire, Strasbourg). Yann Hérault has worked on mouse development from a genetic approach for more than 20 years. He has developed a series of techniques for chromosomal engineering with the aim of studying gene regulation at the genomic level in vivo. His current research interests are focused on evaluating the consequences of gene dosage effect and copy number variation in pathological situations such as in Down Syndrome (or T adrisomy 21) to propose new therapeutic approaches. Yann Hérault did his Ph.D. degree at the University of Lyon in 1993 and continued with post-doctoral training at the University of Geneva from 1993 to 1999 working on Hox gene regulation with Pr.Denis Duboule. He was the former Director of the Transgenesis and Archiving of Animal Models (TAAM) unit from late 2007 to early 2014. He is the coordinator of PHENOMIN, the National Infrastructure for mouse phenogenomics, and the large-scale infrastructure CELPHEDIA for animal models.

Dott. Tania SORG-GUSS 

She is the Chief Operating Officer of the Institut Clinique de la Souris (ICS) and Head of the Phenotyping department. Tania Sorg received her Ph.D. degree in Molecular and Cellular Biology from the University of Strasbourg in 1996. Between 1996 and 2001, she worked as a scientist and project leader at Transgene, Strasbourg, in the field of Gene therapy. Between 2001 and 2003, she became Head of the Technology department at Deltagen Europe, Strasbourg, working in the drug discovery field. She joined the ICS as COO in May 2003 to manage the facility (general management of 12 team leaders, a total of about 80 persons), including the establishment and supervision of scientific projects. She is also Head of the phenotyping department in charge of the functional characterization of mouse and rat models, as well as compound studies (proof-of-concept and side effect studies), covering the major physiological systems (behavior, cognition, sensory systems, cardiology, respiratory system, metabolism and nutrition, clinical chemistry, anatomy-pathology, oncology).

Dott.Mohammed Selloum

He is the Project Manager of European programs at the Institut Clinique de la Souris (ICS). He was trained as an industrial pharmacist. From 1999 to 2001, he worked at Strasbourg Hospital as a resident in the clinical biochemistry and emergency department (headed by Prof. Chambon). He was in charge of medical validation of biochemistry analysis as well as participating in the establishment of GBEA (clinical chemistry lab accreditation). Mohammed Selloum joined the ICS in 2001 as an assistant at the Biochemistry/Metabolism service then pointed in 2008 as a European program manager at the ICS and contributed to several successful European-funded projects with other European mouse clinics (EUMORPHIA and EUMODIC and INFRAFRONTIER).

Dott. Hugues Jacobs 

He is the head of the Anatomy and Histopathology facility. He did his Ph.D. (2009) and his post-doctoral training at Strasbourg University working on retinoic acid metabolism and dioxins embryonic toxicity. He is an expert in rodent anatomy and histology and holds solid expertise in preclinical studies using genetically engineered rodent models. Besides pathology, he is also strongly committed to imaging, participating in optical imaging systems development, and developing innovative tools for image and data analyses.

Fabrice Riet (M)

He is the Head of the Behavior and Cognition team. He has a professional master's degree in " psychopharmacology of cognitive processes&quot. He joined the Institut Clinique de la Souris (ICS) in 2002 as an Engineer in the Behavior and Cognition group and is Head of the team since 2019. With his strong practical knowledge, he is an expert in behavioral analyses and in the implementation and optimization of preclinical tests in rodents, covering most areas such as general health & basic sensory functions, circadian activity & biological rhythm, sensorimotor abilities, anxiety-related & social behavior, depression-like behavior, learning & memory, pain sensitivity, sensorimotor gating/schizophrenia, and epilepsy/seizure susceptibility. He is also in charge of the exploration of the sensory systems (vision and audition) and has all the skills for various routes of administration of compounds or viral vectors, including stereotactic injection.